MyBioSource.com's Axis inhibition protein 2 is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Axis inhibition protein 2 Antibody was generated using AXIN2, CEP112, and Conductin as the antigen and it reacts with Human.
Description
DNA repair mechanism is important for cellular integrity and continuity of cell cycle. The complete and successful DNA repair within the chromatin require orchestrated interplay of histone modifiers, chaperone and remodelers for allowing access for repairs and checkpoint complexes to the damage site. Following the repairs, the restoration of chromatin structure and important epigenetic markers restore the normal cellular functions. The ASF1A participate in a variety of DNA and chromatin related processes including damage and chromatin assembly and disassembly. The histone chaperone, anti-silencing function 1A (ASF1A) is crucial for post repair histone H3 acetylation at K56 and is needed for de-phosphorylation of gamma-H2AX and cellular recovery form the checkpoint arrest (1).
The ASF1A family-selective antibodies were generated against unique peptide taken form with in the amino acid range 60-120